Ethanol → Tert-butyl 3-(6-(5-cyclopentylbenzofuran-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

HRID 139418Notes

Reaction equation

HRID 139418 reaction equation
[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[CH3:52][CH2:53][OH:54].[CH:1]1([c:6]2[cH:7][cH:8][c:9]3[c:10]([cH:11][c:12]([B:14]([OH:15])[OH:16])[o:13]3)[cH:17]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[F:18][C:19]([F:20])([F:21])[S:22]([O:23][c:24]1[cH:25][c:26]2[c:31]([cH:32][cH:33]1)[CH2:30][N:29]([CH2:34][CH2:35][C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])[CH2:28][CH2:27]2)(=[O:43])=[O:44].[Pd:55]([Cl:56])[Cl:57].[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1.[c:77]1([P:78]([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[cH:91][cH:92][cH:93][cH:94][cH:95]1>>[CH:1]1([c:6]2[cH:7][cH:8][c:9]3[c:10]([cH:11][c:12](-[c:24]4[cH:25][c:26]5[c:31]([cH:32][cH:33]4)[CH2:30][N:29]([CH2:34][CH2:35][C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])[CH2:28][CH2:27]5)[o:13]3)[cH:17]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

7

Reactant 6

HCID 702EthanolHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 59595848HCID 59595848, compoundHCID 59595895HCID 59595895, compound

Product 1

HCID 59595930Tert-butyl 3-(6-(5-cyclopentylbenzofuran-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

Sources & evidence

ORD record
ord-68447706f2d44126a7d02e721409d9d5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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