Sodium Hydroxide → HCID 69158965, compound

HRID 1394204Notes

Reaction equation

HRID 1394204 reaction equation
O1[C:5]2([CH2:10][CH2:9][N:8]([CH2:11][C:12]3[C:13]4[N:20]([CH2:21][CH3:22])[C:19]([C:23]5[C:24]([NH2:28])=[N:25][O:26][N:27]=5)=[N:18][C:14]=4[CH:15]=[N:16][CH:17]=3)[CH2:7][CH2:6]2)[O:4]CC1.[OH-].[Na+]>O1CCOCC1.Cl>[NH2:28][C:24]1[C:23]([C:19]2[N:20]([CH2:21][CH3:22])[C:13]3[C:12]([CH2:11][N:8]4[CH2:7][CH2:6][C:5](=[O:4])[CH2:10][CH2:9]4)=[CH:17][N:16]=[CH:15][C:14]=3[N:18]=2)=[N:27][O:26][N:25]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 69159360HCID 69159360, compound

Product 1

HCID 69158965HCID 69158965, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The product from Step 1 (0.245 g, 0.64 mmole) in 1,4-dioxane (20 ml) and aqueous hydrochloric acid (5M, 10 ml) was heated under reflux for 18 hours. The mixture was allowed to cool to ambient temperature, neutralised by addition of aqueous sodium hydroxide solution (5M) and extracted into dichloromethane.

Workup

  1. temperatureunder reflux for 18 hours
  2. extractionextracted into dichloromethane

Sources & evidence

ORD record
ord-cdd082d6d0884e4fac6ade4a4c320331
Source dataset
uspto-grants-2008_03
Patent number
US07348339B2

Reaction notes

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