反应详情

To 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) was added 4N-hydrogen chloride in ethyl acetate (100 ml), and the solution was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the concentrate was added diethyl ether. The resulting precipitates were collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the titled compound (30.1 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionto the concentrate was added diethyl ether
3. customThe resulting precipitates
4. filtrationwere collected by filtration
5. washwashed with diethyl ether
6. customdried under reduced pressure