Lithium Hydroxide → HCID 66896668, compound

HRID 1394594Notes

Reaction equation

HRID 1394594 reaction equation
C([O:3][C:4](=[O:33])[CH:5]=[C:6]([C:8]1[O:12][C:11]2[C:13]([C:17]3[CH:22]=[C:21]([CH:23]([CH3:25])[CH3:24])[CH:20]=[C:19]([CH:26]([CH3:28])[CH3:27])[C:18]=3[O:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:15]=[CH:16][C:10]=2[CH:9]=1)[CH3:7])C.C1COCC1.[Li+].[OH-]>CO>[CH2:30]([O:29][C:18]1[C:19]([CH:26]([CH3:28])[CH3:27])=[CH:20][C:21]([CH:23]([CH3:24])[CH3:25])=[CH:22][C:17]=1[C:13]1[C:11]2[O:12][C:8]([C:6]([CH3:7])=[CH:5][C:4]([OH:33])=[O:3])=[CH:9][C:10]=2[CH:16]=[CH:15][CH:14]=1)[CH2:31][CH3:32]

Participants

5

Reactant 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 69219567HCID 69219567, compound

Product 1

HCID 66896668HCID 66896668, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.450 mmol of 3-[7-(2-propoxy-3,5-diisopropylphenyl)-benzo[b]furan-2-yl]-but-2-enoic acid ethyl ester, 3 mL of THF, 3 mL of methanol and 1 mL of LiOH (2N aqueous) was refluxed for 2 hours. After cooling at room temperature, the mixture was acidified to pH=2 and extracted with ethyl acetate. The organic layer was dried over MgSO4 and after evaporation of the solvents, the crude acid was recrystallized from acetonitrile. 3-[7-(2-Propoxy-3,5-diisopropylphenyl)-benzo[b]furan-2-yl]-but-2-enoic acid was isolated as a white solid. 1H-NMR (400 MHz, CDCl3) δ 7.55 (m, 2H, Ar—H), 7.54 (s, 1H, Ar—H), 7.28 (t, J=7.6 Hz, 1H, Ar—H), 7.10 (s, 1H, furan-H), 6.94 (s, 1H, Ar—H), 6.62 (s, 1H, C═C—H), 4.06 (q, J=6.9 Hz, 2H, O—CH2—CH3), 2.56 (s, 3H, C═C—CH3), 1.74 (s, 4H, ring-CH2), 1.37 (s, 6H, ring-CH3), 1.33 (s, 6H, ring-CH3), 1.27 (t, J=6.9 Hz, 3H, O—CH2—CH3).

Workup

  1. temperaturewas refluxed for 2 hours
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over MgSO4
  4. customafter evaporation of the solvents
  5. customthe crude acid was recrystallized from acetonitrile

Sources & evidence

ORD record
ord-af2c5aceb27a406ba70fe0ed4d50feeb
Source dataset
uspto-grants-2008_03
Patent number
US07348359B2

Reaction notes

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