Methyl morpholine oxide → 3-(2-Ethoxy-3,5-diisopropyl-phenyl)-imidazo[1,2-a]pyridine-6-carbaldehyde

HRID 1394654Notes

Reaction equation

HRID 1394654 reaction equation
C[N+]1([O-])CCOCC1.[CH2:9]([O:11][C:12]1[C:17]([CH:18]([CH3:20])[CH3:19])=[CH:16][C:15]([CH:21]([CH3:23])[CH3:22])=[CH:14][C:13]=1[C:24]1[N:28]2[CH:29]=[C:30]([CH2:33][OH:34])[CH:31]=[CH:32][C:27]2=[N:26][CH:25]=1)[CH3:10]>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH2:9]([O:11][C:12]1[C:17]([CH:18]([CH3:19])[CH3:20])=[CH:16][C:15]([CH:21]([CH3:23])[CH3:22])=[CH:14][C:13]=1[C:24]1[N:28]2[CH:29]=[C:30]([CH:33]=[O:34])[CH:31]=[CH:32][C:27]2=[N:26][CH:25]=1)[CH3:10]

Participants

5

Reactant 2

HCID 82029Methyl morpholine oxideHCID 59682036HCID 59682036, compound

Product 1

HCID 179527243-(2-Ethoxy-3,5-diisopropyl-phenyl)-imidazo[1,2-a]pyridine-6-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178419074HCID 178419074, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Tetrapropylammonium perruthenate (24 mg, 0.07 mmol) and 4-methylmorpholine N-oxide (239.3 mg, 2.04 mmol) were added to a solution of [3-(2-ethoxy-3,5-diisopropyl-phenyl)-imidazo[1,2-a]pyridin-6-yl]-methanol (480 mg, 1.36 mmol) in dichloromethane under an atmosphere of nitrogen. After 3 h, the reaction was filtered through celite and evaporated. The residue used without further purification.

Workup

  1. filtrationthe reaction was filtered through celite
  2. customevaporated
  3. customThe residue used without further purification

Sources & evidence

ORD record
ord-408273f4821a4c6ca80161009035dabb
Source dataset
uspto-grants-2008_03
Patent number
US07348359B2

Reaction notes

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