Phosphorus oxychloride → 4-Chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole

HRID 1394684Notes

Reaction equation

HRID 1394684 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:15])=[C:11]([CH3:14])[N+:12]=2[O-])=[CH:4][C:3]=1[CH3:16].P(Cl)(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[Cl:19][CH2:14][C:11]1[N:12]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:16])[CH:4]=2)[O:9][C:10]=1[CH3:15]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 22273855HCID 22273855, compound

Product 1

HCID 219742594-Chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In analogy to the procedure described in example 2 b], 2-(4-fluoro-3-methyl-phenyl)-4,5-dimethyl-oxazole 3-oxide was treated with phosphorous oxychloride in chloroform to yield 4-chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole as colorless solid.

Sources & evidence

ORD record
ord-94f55a9be3b54526847e02aa35c642c0
Source dataset
uspto-grants-2008_03
Patent number
US07348349B2

Reaction notes

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