Tert-Butylamine → HCID 20341547, compound

HRID 1395056Notes

Reaction equation

HRID 1395056 reaction equation
[O:1]1[CH2:22][CH:2]1[CH2:3][O:4][C:5]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=[O:8].[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24]>CO>[C:23]([NH:27][CH2:22][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=[O:8])([CH3:26])([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 20341515{2,4-Dimethyl-6-[(oxiran-2-yl)methoxy]phenyl}(4-methylphenyl)methanone

Product 1

HCID 20341547HCID 20341547, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-(2,3-epoxypropoxy)-4,4',6-trimethylbenzophenone (10 g.), t-butylamine (10 ml.) and dry methanol (50 ml.) was heated at reflux overnight. The mixture was evaporated in vacuo, and the residue was recrystallized from cyclohexane to give DL-1-t-butylamino-3-(3,5-dimethyl-2-p-toluoylphenoxy)-2-hydroxypropane (7 g.), m.p. 116°-118° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. customThe mixture was evaporated in vacuo
  4. customthe residue was recrystallized from cyclohexane

Sources & evidence

ORD record
ord-ea2b4652679040d5b21b03dd8d85f9ba
Source dataset
uspto-grants-1980_05
Patent number
US04201790

Reaction notes

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