反应详情

To a solution of 1.06 g. of 3-mercaptopropionic acid in 5 ml. of toluene and 2.0 g. of triethylamine, there was added with cooling 1.83 g. of p-chlorobenzylisothiocyanate. Two phases formed. The mixture was acidified with 1-N hydrochloric acid and extracted with chloroform. The chloroform phases were washed with water, dried over magnesium sulfate and concentrated. The residue was recrystallized from acetonitrile, and 2.1 g. of 3-{[(p-chlorobenzyl)thiocarbamoyl]thio}-propionic acid having a melting point of 126°-127° C. were obtained.

1. temperaturewith cooling 1.83 g
2. customTwo phases formed
3. extractionextracted with chloroform
4. washThe chloroform phases were washed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customThe residue was recrystallized from acetonitrile, and 2.1 g