2-Bromoethanol → HCID 3051839, compound

HRID 1395430Notes

Reaction equation

HRID 1395430 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:7][C:8]=1[F:9].Br[CH2:19][CH2:20][OH:21]>C(O)CCC>[F:17][C:2]([F:16])([F:1])[C:3]1[CH:4]=[C:5]([N:10]2[CH2:11][CH2:12][N:13]([CH2:19][CH2:20][OH:21])[CH2:14][CH2:15]2)[CH:6]=[CH:7][C:8]=1[F:9]

Participants

4

Reactant 2

HCID 108982-BromoethanolHCID 22345216HCID 22345216, compound

Product 1

HCID 3051839HCID 3051839, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

10 g (0.04 mole) 4-(3-Trifluoromethyl-4-fluorophenyl)piperazine and 7 g (0.056 mole) 2-bromoethanol are heated under reflux for 4 hours in 60 ml n-butanol. The mixture is left to cool, filtered and then recrystallised from ethanol.

Workup

  1. waitThe mixture is left
  2. temperatureto cool
  3. filtrationfiltered
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-50d9b4073e544fca828a272c53607494
Source dataset
uspto-grants-1980_05
Patent number
US04203986

Reaction notes

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