反应详情

A solution of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)-ethyl]-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one in 120 ml. water and 60 ml. ethanol containing 14 ml. conc. hydrochloric acid, was shaken with 1.2 g. of PtO2 under 45 psi. hydrogen pressure. Solution was filtered, concentrated under vacuum, and residue crystallized once from ethanol and then from methanol. After filtration and drying the dihydrochloride salt of the title compound had a m.p. of 268°-271° C. (dec.); yield: 3.5 g.

1. filtrationSolution was filtered
2. concentrationconcentrated under vacuum, and residue
3. customcrystallized once from ethanol
4. filtrationAfter filtration
5. dry with materialdrying the dihydrochloride salt of the title compound