Methanesulfonic Acid → HCID 53702875, compound

HRID 1395481Notes

Reaction equation

HRID 1395481 reaction equation
[CH:1]([CH:14]1[CH2:19][CH2:18][CH2:17][N:16]([C:20](=[O:27])[CH2:21][O:22][CH2:23][C:24]([OH:26])=[O:25])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:28]S(O)(=O)=O>CO>[CH:1]([CH:14]1[CH2:19][CH2:18][CH2:17][N:16]([C:20](=[O:27])[CH2:21][O:22][CH2:23][C:24]([O:26][CH3:28])=[O:25])[CH2:15]1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 20339690HCID 20339690, compound

Product 1

HCID 53702875HCID 53702875, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner similar to that described in Example XXVI, 3.63 grams (10 millimoles) of [2-(3-benzhydrylpiperidino)-2-oxoethoxy]acetic acid (Example VIII), 150 milliliters of methanol and 300 milligrams of methanesulfonic acid are stirred together for about six hours at ambient temperature. Thereafter, the methanol is evaporated, the residue dissolved in ether, the ether solution washed, dried and the solvent evaporated to obtain a methyl [2-(3-benzhydrylpiperidino)-2-oxoethoxy]acetate product as residue.

Workup

  1. customThereafter, the methanol is evaporated
  2. dissolutionthe residue dissolved in ether
  3. washthe ether solution washed
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-90c41539cd194f4fa3c052007e4b5166
Source dataset
uspto-grants-1980_05
Patent number
US04203991

Reaction notes

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