Urea → HCID 20339531, compound

HRID 1395544Notes

Reaction equation

HRID 1395544 reaction equation
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][N:5]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[N:9]=1)[C:6]#[N:7].[OH-].[Na+].NC(N)=[O:21]>Cl>[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][N:5]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[N:9]=1)[C:6]([NH2:7])=[O:21]

Participants

5

Reactant 3

HCID 1176UreaHCID 14798Sodium HydroxideHCID 20339433HCID 20339433, compound

Product 1

HCID 20339531HCID 20339531, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of N-(2-dimethylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)cyanamide (5.66 g., 0.026 mole) in 6 N hydrochloric acid (60 ml.) is allowed to sit at room temperature for 11/2 hour. The reaction solution was then cooled, made alkaline (pH about 11) with 50% sodium hydroxide solution, and extracted with ether. After washing with water and drying over anhydrous magnesium sulfate, the combined extracts are taken to dryness in vacuum. Recrystallization of the residue from hexane gives 3.90 g. of product urea, m.p. 88°-89° C.

Workup

  1. customto sit at room temperature for 11
  2. custom2 hour
  3. temperatureThe reaction solution was then cooled
  4. extractionextracted with ether
  5. washAfter washing with water
  6. dry with materialdrying over anhydrous magnesium sulfate
  7. customRecrystallization of the residue from hexane
  8. customgives 3.90 g

Sources & evidence

ORD record
ord-2ef98d90844e4b41b3d133c6871ee60d
Source dataset
uspto-grants-1980_05
Patent number
US04203988

Reaction notes

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