Hydrochloric Acid → ((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

HRID 1395572Notes

Reaction equation

HRID 1395572 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]([OH:8])=[O:7].[CH3:9]OC(OC)(C)C.[ClH:16]>CO>[ClH:16].[CH3:9][O:7][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH2:1])=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 4474780HCID 4474780, compound

Product 1

HCID 170337((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

13.5 g of S-(β-aminoethyl)mercaptoacetic acid and 10.8 g of 2,2-dimethoxy propane are added, successively, to a solution of 7.3 g of gaseous hydrochloric acid in 20 cc of methanol. The solution is permitted to stand for 12 hours at ambient temperature. The flakes formed (17.5 g) are filtered and washed with ethyl acetate. Fusion point=100° C.

Workup

  1. customThe flakes formed (17.5 g)
  2. filtrationare filtered
  3. washwashed with ethyl acetate
  4. customFusion point=100° C.

Sources & evidence

ORD record
ord-22b06dce01664df9b70cac09cc33e009
Source dataset
uspto-grants-1980_05
Patent number
US04204064

Reaction notes

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