Butyl bromide → HCID 20340027, compound

HRID 1395591Notes

Reaction equation

HRID 1395591 reaction equation
[Na].[CH2:2]([O:4][C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:16](=[O:26])[NH:15][C:14]1=[O:27])=[O:6])[CH3:3].[CH2:28](Br)[CH2:29][CH2:30][CH3:31]>C(O)C>[CH2:28]([N:15]1[C:14](=[O:27])[CH:13]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]([O:4][CH2:2][CH3:3])=[O:6])[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:16]1=[O:26])[CH2:29][CH2:30][CH3:31]

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 5360545SodiumHCID 12788655HCID 12788655, compound

Product 1

HCID 20340027HCID 20340027, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of sodium (308 mg) in ethanol (40 ml) was added 5-(6-ethoxycarbonylhexyl)-1-octylhydantoin (see Example 29b), followed by butyl bromide (1.8 g), and the solution was refluxed for 24 hours. The solvent was evaporated, water was added and the insoluble oil was extracted with ether. The washed and dried extract was evaporated to give 3-butyl-5-(6-ethoxycarbonylhexyl)-1-octylhydantoin.

Workup

  1. temperaturethe solution was refluxed for 24 hours
  2. customThe solvent was evaporated
  3. additionwater was added
  4. extractionthe insoluble oil was extracted with ether
  5. washThe washed
  6. customdried
  7. extractionextract
  8. customwas evaporated

Sources & evidence

ORD record
ord-7d94d3eac76341e690c8378e70a273be
Source dataset
uspto-grants-1980_05
Patent number
US04204068

Reaction notes

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