Aniline → 2-anilinoacetophenone

HRID 1395620Notes

Reaction equation

HRID 1395620 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[NH:11]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 6259Phenacyl bromide

Product 1

HCID 11326242-anilinoacetophenone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 g of ω-bromoacetophenone are dissolved in 600 ml of absolute ethanol, followed by the dropwise addition at 20° C. of 100 g of aniline. On completion of the addition, the ω-anilinoacetophenone formed precipitates in crystalline form. Yield: 62 g=59%; m.p: 97°-99° C.

Workup

  1. additionOn completion of the addition

Sources & evidence

ORD record
ord-a199748a486c4f828cfb82e1f4a92777
Source dataset
uspto-grants-1980_05
Patent number
US04204867

Reaction notes

Loading…