Hydrochloric Acid → HCID 20574338, compound

HRID 1395671Notes

Reaction equation

HRID 1395671 reaction equation
[CH2:1]([N:3]1[CH2:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:5]([OH:14])[C:4]1=[O:15])[CH3:2].[N:16]1([CH2:22][CH2:23]Cl)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.Cl>C(OCC)(=O)C>[CH2:1]([N:3]1[CH2:7][C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[C:5]([O:14][CH2:23][CH2:22][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:4]1=[O:15])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 748271-(2-Chloroethyl)piperidineHCID 20574348HCID 20574348, compound

Product 1

HCID 20574338HCID 20574338, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1, 30.5 g. 1-ethyl-3-hydroxy-4-phenyl-3-pyrrolin-2-one is reacted with 21.5 g. β-piperidinoethyl chloride. The base obtained is converted into the crystalline hydrochloride in ethyl acetate by means of gaseous hydrogen chloride. There is obtained 22.5 g. (42% of theory) 1-ethyl-3-(β-piperidinoethoxy)-4-phenyl-3-pyrrolidin-2-one hydrochloride; m.p. 120° C., (decomp.), after recrystallization from methyl ethyl ketone.

Workup

  1. customThe base obtained
  2. customThere is obtained 22.5 g
  3. customm.p. 120° C., (decomp.), after recrystallization from methyl ethyl ketone

Sources & evidence

ORD record
ord-d7db1b9268e6434a95f9e13f74776fe6
Source dataset
uspto-grants-1980_05
Patent number
US04205078

Reaction notes

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