反应详情

A mixture of 0.99 g of 1A, 0.96 g of diethyl bromomalonate and 1.25 g of anhydrous potassium carbonate in 20 ml of 2-butanone, was refluxed for 10 hours. The solvent was evaporated under reduced pressure. The residue was cooled, poured into 100 ml of water and extracted with ether. The extract was washed with cold 5% sodium hydroxide solution and water and then concentrated under reduced pressure. The residue was recrystallized from ethanol to give ethyl 5-phenylbenzofuran-2-carboxylate (1B), as white crystals, mp: 109°-110° C.

1. temperaturewas refluxed for 10 hours
2. customThe solvent was evaporated under reduced pressure
3. temperatureThe residue was cooled
4. additionpoured into 100 ml of water
5. extractionextracted with ether
6. washThe extract was washed with cold 5% sodium hydroxide solution and water
7. concentrationconcentrated under reduced pressure
8. customThe residue was recrystallized from ethanol