Glycolic Acid → HCID 12939690, compound

HRID 1395691Notes

Reaction equation

HRID 1395691 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:13])=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[CH2:14]([OH:18])[C:15](O)=[O:16]>O>[OH:18][CH2:14][C:15]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:13])=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1)=[O:16]

Participants

4

Reactant 2

HCID 757Glycolic AcidHCID 922497-Amino-4-methylcoumarin

Product 1

HCID 12939690HCID 12939690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.7 g of 7-amino-4-methyl-coumarin are stirred, under nitrogen, in a round-bottomed flask, together with 7.6 g of glycollic acid at an oil bath temperature of 150°-160°. The reaction mass becomes crystalline after about 30 minutes. It is diluted with water and the product is filtered off with suction and recrystallised from 200 ml of dimethylformamide and 100 ml of ethanol. 7-Hydroxyacetamido-4-methyl-coumarin with a melting point of 253°-254° is obtained.

Workup

  1. filtrationthe product is filtered off with suction
  2. customrecrystallised from 200 ml of dimethylformamide and 100 ml of ethanol

Sources & evidence

ORD record
ord-4437a395496846aaa58f48208b4c1de1
Source dataset
uspto-grants-1980_05
Patent number
US04205082

Reaction notes

Loading…