Hydrochloric Acid → HCID 131732103, compound

HRID 1396028Notes

Reaction equation

HRID 1396028 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]2[CH:24]=[CH:23][C:17]3[O:18][C:19]([F:22])([F:21])[O:20][C:16]=3[CH:15]=2)[CH2:9]1)=O)(C)(C)C.[ClH:25]>ClCCl>[ClH:25].[F:22][C:19]1([F:21])[O:18][C:17]2[CH:23]=[CH:24][C:14]([CH2:13][CH:10]3[CH2:11][CH2:12][NH:8][CH2:9]3)=[CH:15][C:16]=2[O:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66974052HCID 66974052, compound

Product 1

HCID 131732103HCID 131732103, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution consisting of 3-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.36 g, 3.98 mmol) and dichloromethane (20 mL) was added HCl (4 M solution in dioxane, 6 mL). The reaction mixture was stirred at rt for 18 h. The resultant mixture was concentrated to give the title compound in quantitative yield.

Workup

  1. concentrationThe resultant mixture was concentrated

Sources & evidence

ORD record
ord-f4bd942d89134a7f9edaf912f71978b9
Source dataset
uspto-grants-2014_12
Patent number
US08901111B2

Reaction notes

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