Water → HCID 10931845, compound

HRID 1396074Notes

Reaction equation

HRID 1396074 reaction equation
[O:1]1[CH2:6][CH2:5][C:4](=O)[CH2:3][CH2:2]1.[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.O>C1(C)C=CC=CC=1>[O:1]1[CH2:6][CH:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 121599Tetrahydro-4H-pyran-4-one

Product 1

HCID 10931845HCID 10931845, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

650 mg of tetrahydro-4H-pyran-4-one together with 950 mg of morpholine were dissolved in 10 ml of toluene and the mixture was heated under reflux in a light water separator for 5 hours. Subsequently, the mixture was concentrated under reduced pressure, and residue (1.3 g) was used further without further workup.

Workup

  1. temperaturethe mixture was heated
  2. concentrationSubsequently, the mixture was concentrated under reduced pressure, and residue (1.3 g)

Sources & evidence

ORD record
ord-57ca641536d6442982df03e023b77d34
Source dataset
uspto-grants-2014_12
Patent number
US08901114B2

Reaction notes

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