Tetrahydrofuran → [2-Chloro-6-(3-methylmorpholin-4-yl)pyrimidin-4-yl]methanol

HRID 139644Notes

Reaction equation

HRID 139644 reaction equation
[BH4-:19].[CH2:21]1[O:22][CH2:23][CH2:24][CH2:25]1.[Cl:1][c:2]1[n:3][c:4]([N:12]2[CH:13]([CH3:18])[CH2:14][O:15][CH2:16][CH2:17]2)[cH:5][c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1.[Li+:20]>>[Cl:1][c:2]1[n:3][c:4]([N:12]2[CH:13]([CH3:18])[CH2:14][O:15][CH2:16][CH2:17]2)[cH:5][c:6]([CH2:8][OH:9])[n:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 28123BorohydrideHCID 28486Lithium ionHCID 72282464(R)-methyl2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate

Product 1

HCID 72282660[2-Chloro-6-(3-methylmorpholin-4-yl)pyrimidin-4-yl]methanol

Sources & evidence

ORD record
ord-bf53d765d0ee40858b541b0103000cfe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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