HCID 68023818, compound → HCID 86710220, compound

HRID 1396494Notes

Reaction equation

HRID 1396494 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:10]=[C:11]([F:24])[C:12]([CH2:15][NH:16]C(=O)OC(C)(C)C)=[N:13][CH:14]=2)=[C:4]([C:25]([F:28])([F:27])[F:26])[CH:3]=1>Cl.O1CCOCC1>[ClH:1].[ClH:1].[NH2:16][CH2:15][C:12]1[N:13]=[CH:14][C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=2[C:25]([F:28])([F:27])[F:26])=[CH:10][C:11]=1[F:24]

Participants

4

Reactant 1

HCID 68023818HCID 68023818, compound

Product 1

HCID 86710220HCID 86710220, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl [5-(4-chloro-2-trifluoromethyl-phenylamino)-3-fluoro-pyridin-2-ylmethyl]-carbamate (50 mg, 0.12 mmol) was stirred for 2 hours at 60° C. in a mixture of 2 mL of semi-concentrated hydrochloric acid and 3 mL of dioxane. This was then concentrated to dryness, the residue was stirred with 3 mL of toluene and evaporated down once more. The product was thus obtained in a yield of 84% of theory.

Workup

  1. concentrationThis was then concentrated to dryness
  2. customevaporated down once more
  3. customThe product was thus obtained in a yield of 84% of theory

Sources & evidence

ORD record
ord-bfbfa87c55204baeb28df7e815445a74
Source dataset
uspto-grants-2014_12
Patent number
US08901127B2

Reaction notes

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