HCID 86706491, compound → HCID 86706490, compound

HRID 1396503Notes

Reaction equation

HRID 1396503 reaction equation
[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:11]([CH2:19][CH2:20][CH2:21][NH:22]C(OC(C)(C)C)=O)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl.O1CCOCC1>[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:11]([CH2:19][CH2:20][CH2:21][NH2:22])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 86706491HCID 86706491, compound

Product 1

HCID 86706490HCID 86706490, compoundYield 104.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Ethyl 3-(benzyloxy)-1-{3-[(tert-butoxycarbonyl)amino]propyl}-1H-pyrazole-5-carboxylate (7 g, 17.4 mmol) was dissolved in a 4 M solution of HCl in 1,4-dioxane (50 mL). The mixture was stirred at room temperature for 1 hour and then the solvent was evaporated in vacuo to yield ethyl 3-(benzyloxy)-1-[3-amino-propyl]-1H-pyrazole-5-carboxylate (5.5 g, 95% yield) that was used in the next step without further purification.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-24b9d79427534af6a8280438d474f11b
Source dataset
uspto-grants-2014_12
Patent number
US08901125B2

Reaction notes

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