HCID 68963802, compound → HCID 136387221, compound

HRID 1396553Notes

Reaction equation

HRID 1396553 reaction equation
C([O:8][C:9]1[C:14]([Cl:15])=[CH:13][C:12]([C:16]2[C:24]3[C:19](=[N:20][C:21]([NH2:25])=[N:22][CH:23]=3)[N:18]([CH3:26])[N:17]=2)=[CH:11][C:10]=1[Cl:27])C1C=CC=CC=1>Br.O>[NH2:25][C:21]1[N:20]=[C:19]2[N:18]([CH3:26])[N:17]=[C:16]([C:12]3[CH:13]=[C:14]([Cl:15])[C:9]([OH:8])=[C:10]([Cl:27])[CH:11]=3)[C:24]2=[CH:23][N:22]=1

Participants

4

Reactant 1

HCID 68963802HCID 68963802, compound

Product 1

HCID 136387221HCID 136387221, compound

Reagents, catalysts & solvents 2

HCID 260Hydrogen BromideSolventHCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

3-(4-Benzyloxy-3,5-dichloro-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (0.2 g, 0.500 mmol) is dissolved in 48% HBr in water (20 ml) and heated to 120° C. for 1 hour. The reaction mixture is cooled to room temperature and the resulting precipitate is collected by filtration and re-crystallised from EtOH to afford the title compound.

Workup

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationthe resulting precipitate is collected by filtration
  3. customre-crystallised from EtOH

Sources & evidence

ORD record
ord-d95ad574336a4f42ac0a11ffd997656d
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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