Hydrochloric Acid → HCID 86701161, compound

HRID 1396674Notes

Reaction equation

HRID 1396674 reaction equation
C([NH:5][C:6]1[C:15]([N+:16]([O-:18])=[O:17])=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([CH:19]=[CH2:20])[CH:7]=1)(C)(C)C.[ClH:21]>CO>[ClH:21].[NH2:5][C:6]1[C:15]([N+:16]([O-:18])=[O:17])=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([CH:19]=[CH2:20])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86701159HCID 86701159, compound

Product 1

HCID 86701161HCID 86701161, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 3.74 g of methyl 4-(tert-butylamino)-5-nitro-2-vinylbenzoate and 37.4 mL of methanol was added 21.7 mL of 6 M hydrochloric acid, followed by heating to reflux for 1 hour. The reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration. The obtained solid was dried at 40° C. for 2 hours under reduced pressure to obtain 2.56 g of methyl 4-amino-5-nitro-2-vinylbenzoate monohydrochloride as a yellow solid.

Workup

  1. temperatureby heating
  2. temperatureto reflux for 1 hour
  3. filtrationthe precipitated solid was collected by filtration
  4. customThe obtained solid was dried at 40° C. for 2 hours under reduced pressure

Sources & evidence

ORD record
ord-a4d201a41eac4a249fd36aad8e1ee889
Source dataset
uspto-grants-2014_12
Patent number
US08901126B2

Reaction notes

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