4-Bromophenacyl bromide → 4-(4-Bromophenyl)-2-thiazoleacetonitrile

HRID 1397251Notes

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[C:12]([CH2:14][C:15]([NH2:17])=[S:16])#[N:13]>>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:17]=[C:15]([CH2:14][C:12]#[N:13])[S:16][CH:2]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 74544-Bromophenacyl bromide

HCID 14162772-Cyanoethanethioamide

Product 1

HCID 27906204-(4-Bromophenyl)-2-thiazoleacetonitrileYield 48%

Procedure

This compound was synthesized from 2-bromo-1-(4-bromophenyl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (2.4 g, 48% yield), and it was carried through without further purification. MS (ESI) m/z: Calculated for C11H7BrN2S: 277.95. found: 279.0 (M+H)+.

Workup

customwas carried through without further purification

Sources & evidence

ORD record: ord-4254781229e94dea8ceacebd8ebfc54f
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08901156B2

Reaction notes

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