Hydrochloric Acid → HCID 67325165, compound

HRID 1397454Notes

Reaction equation

HRID 1397454 reaction equation
[OH-].[Na+].[F:3][C:4]([F:26])([F:25])[C:5]1[O:9][N:8]=[C:7]([C:10]2[CH:11]=[C:12]([CH:22]=[CH:23][CH:24]=2)[C:13]([NH:15][CH2:16][CH2:17][C:18]([O:20]C)=[O:19])=[O:14])[N:6]=1.Cl>C1COCC1.CO.O>[F:25][C:4]([F:3])([F:26])[C:5]1[O:9][N:8]=[C:7]([C:10]2[CH:11]=[C:12]([CH:22]=[CH:23][CH:24]=2)[C:13]([NH:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[O:14])[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67324027HCID 67324027, compound

Product 1

HCID 67325165HCID 67325165, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

A sodium hydroxide solution (0.2 mL, 5 M) was added to a solution of methyl 3-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)propanoate in THF/MeOH/water (4:1:1, 15 mL). The reaction was stirred for 30 min and acidified with 2 M HCl. The reaction was extracted with ethyl acetate several times, dried over sodium sulfate, and used crude. MS (ESI) m/z: Calculated for C13H10F3N3O4: 329.06. found: 330.1 (M+H)+.

Workup

  1. extractionThe reaction was extracted with ethyl acetate several times
  2. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-39da1f1daf0e43f8836e3a927362e4e9
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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