Hydrochloric Acid → HCID 66607849, compound

HRID 1398169Notes

Reaction equation

HRID 1398169 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]([NH:17][NH:18]C(OC(C)(C)C)=O)=[O:16])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[ClH:26]>C(OCC)(=O)C>[ClH:26].[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1)[C:15]([NH:17][NH2:18])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66608673tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate

Product 1

HCID 66607849HCID 66607849, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a mixture of tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate (8.00 g) in ethyl acetate (50 mL) was added hydrogen chloride (4-Methyl acetate solution, 100 mL), and the mixture was stirred at room temperature overnight. Ethyl acetate was added to the reaction mixture, and the precipitate was collected by filtration. The solid was recrystallized from methanol/ethyl acetate to give the title compound (5.94 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customThe solid was recrystallized from methanol/ethyl acetate

Sources & evidence

ORD record
ord-ab0f4a3b5a324fe19c06c9a7003f1dcc
Source dataset
uspto-grants-2014_12
Patent number
US08901309B2

Reaction notes

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