Thionyl Chloride → HCID 117716382, compound

HRID 1398250Notes

Reaction equation

HRID 1398250 reaction equation
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](O)=[O:15])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:21])=O>CN(C)C=O>[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([Cl:21])=[O:15])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 223889056-(4-Nitrophenoxy)hexanoic acid

Product 1

HCID 117716382HCID 117716382, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 6-(4-nitrophenoxy)-hexanoic acid (20 g), thionyl chloride (40 ml) and dimethylformamide (0.5 ml) was refluxed for 5 hours. Excess thionyl chloride was distilled off under reduced pressure. Dry toluene (20 ml) added and solvent was removed under reduced pressure to obtain 6-(4-nitrophenoxy)-hexanoyl chloride (20 grams) as light yellow oil.

Workup

  1. temperaturewas refluxed for 5 hours
  2. distillationExcess thionyl chloride was distilled off under reduced pressure
  3. additionDry toluene (20 ml) added
  4. customsolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c94c4f5ed5864f70acdb4e05e49d4f36
Source dataset
uspto-grants-2014_12
Patent number
US08901347B1

Reaction notes

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