Sodium sulfate decahydrate → HCID 57786182, compound

HRID 1399352Notes

Reaction equation

HRID 1399352 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([C:30](OC)=[O:31])=[C:12]2[C:16]=1[N:15]=[C:14]1[CH:17]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=3[Cl:29])[O:18][CH2:19][CH2:20][CH2:21][N:13]21.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[Cl:7][C:8]1[C:16]2[N:15]=[C:14]3[CH:17]([C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=4[Cl:29])[O:18][CH2:19][CH2:20][CH2:21][N:13]3[C:12]=2[C:11]([CH2:30][OH:31])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 62649Sodium sulfate decahydrateHCID 21226445Aluminium lithium hydrideHCID 57786046HCID 57786046, compound

Product 1

HCID 57786182HCID 57786182, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of lithium aluminum hydride (35.7 mg, 0.940 mmol) in tetrahydrofuran (2 mL) was added a solution of methyl 10-chloro-1-(2,4-dichlorophenyl)-4,5-dihydro-1H,3H-[1,4]oxazepino[4,3-a]benzimidazole-7-carboxylate (200 mg, 0.470 mmol) in tetrahydrofuran (2 mL) at 0° C. After 5 min, sodium sulfate decahydrate was added. After 30 min, the resultant mixture was filtrated and concentrated in vacuo to give the title compound as a colorless solid (187 mg, 0.470 mmol, 100%).

Workup

  1. waitAfter 30 min
  2. filtrationthe resultant mixture was filtrated
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2678ec48e55b4f07a24a64035641fb7c
Source dataset
uspto-grants-2014_12
Patent number
US08901141B2

Reaction notes

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