反应详情

A mixture of spray-dried KF (80 mg, 1.392 mmol), intermediate 1 (100 mg, 0.2785 mmol) and catalytic amount of 18-crown-6 in dry DMSO (2 mL) was irradiated using house hold microwave oven for 1.5 min. Work-up of the reaction mixture as described in example 1 (method A) gave benzyl 2-(2-fluoro-4-nitrobenzamido)acetate as a pale yellow color solid (106 mg, 46%), mp 104-106° C. Which was further reduced as described in example 1 gave compound 1.

1. customwas irradiated
2. customfor 1.5 min