HRID1399539

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID123564

tert-Butyldimethylsilyl trifluoromethanesulphonate

C7H15F3O3SSi

$结构：C/C=C(\O[Si](C)(C)C(C)(C)C)c1cccc(Cl)c1$

HCID11300561

未命名化合物

HCID12231712

3-Fluoro-1-phenylpropan-1-one

C9H9FO

PRODUCTS

生成物

$结构：C/C=C(\O[Si](C)(C)C(C)(C)C)c1cccc(F)c1$

HCID46837928

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Compound 9c was synthesized by a procedure similar to that described for 9a using commercially available 3-fluoropropiophenone (8c, 5.0 g, 0.033 mol), TBDMSOTf (8.3 mL, 36.1 mmol), and Et3N (7.3 mL) in CH2Cl2 (50 mL). After purification, 8.1 g (93%) of 9c was isolated as colorless oil: 1H NMR (CDCl3) δ 7.38-7.10 (m, 2H), 7.00-6.87 (m, 1H), 5.26 (q, 1H, J=6.9 Hz), 1.75 (d, 3H, J=6.9 Hz), 1.00 (s, 9H), −0.02 (s, 6H); 13C NMR (CDCl3) δ 164.5, 161.2, 149.2, 142.4, 129.4, 121.4, 114.3, 114.0, 112.8, 112.5, 107.1, 105.9, 26.0, 18.5, 11.9, −3.9. C15H23FOSi.

WORKUP

后处理

customCompound 9c was synthesized by a procedure similar to
customAfter purification