反应详情

Methyl 2-(2-(azepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate was prepared according to the general method A starting from azepane (0.152 mL; 1.32 mmol) and methyl 2-(2-chloro-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate (0.110 g; 0.264 mmol) in tetrahydrofuran (2 mL). Purification by flash-chromatography on silica gel using a gradient of ethyl acetate (5-15%) in heptane furnished 91 mg (87%) of the title compound as an oil. ESI/APCI(+): 396(M+H), 418 (M+Na). ESI/APCI(−): 394 (M−H).

1. customMethyl 2-(2-(azepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate was prepared
2. customPurification by flash-chromatography on silica gel using a gradient of ethyl acetate (5-15%) in heptane