Hydrochloric Acid → HCID 71765337, compound

HRID 1399985Notes

Reaction equation

HRID 1399985 reaction equation
[CH2:1]([N:3]1CN(C)C[N:5]([C:10]2[S:11][C:12]3[C:18]([C:19]4[CH:24]=[C:23]([CH2:25][N:26]5[CH2:29][C:28]([OH:31])([CH3:30])[CH2:27]5)[CH:22]=[CH:21][N:20]=4)=[CH:17][C:16]([C:32]4[CH:33]=[N:34][C:35]([C:38]([OH:41])([CH3:40])[CH3:39])=[N:36][CH:37]=4)=[CH:15][C:13]=3[N:14]=2)[C:4]1=[O:42])[CH3:2].Cl>CO.C(Cl)Cl>[CH2:1]([NH:3][C:4]([NH:5][C:10]1[S:11][C:12]2[C:18]([C:19]3[CH:24]=[C:23]([CH2:25][N:26]4[CH2:27][C:28]([OH:31])([CH3:30])[CH2:29]4)[CH:22]=[CH:21][N:20]=3)=[CH:17][C:16]([C:32]3[CH:33]=[N:34][C:35]([C:38]([OH:41])([CH3:40])[CH3:39])=[N:36][CH:37]=3)=[CH:15][C:13]=2[N:14]=1)=[O:42])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86696898HCID 86696898, compound

Product 1

HCID 71765337HCID 71765337, compoundYield 100.4%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

An ice-cold solution of ii (0.25 g, 0.42 mmol) in MeOH-DCM (0.50 and 10 mL respectively) was purged with HCl (g) for 10 min and the mixture stirred at RT for 16 h. The solvent was evaporated and the residue triturated with a mixture of MeOH and Et2O to obtain Compound 2 (0.225 g, 90%).

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated with a mixture of MeOH and Et2O

Sources & evidence

ORD record
ord-1efdb64d86c941099cc5722482c82399
Source dataset
uspto-grants-2014_12
Patent number
US08906902B2

Reaction notes

Loading…