HCID 72724619, compound → [2-Amino-7-(2-pyridyl)-1,3-benzothiazol-5-yl]trifluoromethanesulfonate

HRID 1399990Notes

Reaction equation

C(NC([NH:6][C:7]1[S:8][C:9]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][C:13]([O:22][S:23]([C:26]([F:29])([F:28])[F:27])(=[O:25])=[O:24])=[CH:12][C:10]=2[N:11]=1)=O)C>CS(C)=O.CCOC(C)=O>[NH2:6][C:7]1[S:8][C:9]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][C:13]([O:22][S:23]([C:26]([F:27])([F:29])[F:28])(=[O:25])=[O:24])=[CH:12][C:10]=2[N:11]=1

Participants

Conditions

Temperature: 160 °C

Procedure

[2-(ethylcarbamoylamino)-7-(2-pyridyl)-1,3-benzothiazol-5-yl]trifluoromethanesulfonate (1.34 g, 3.0 mmol) was dissolved in DMSO (10 mL) and stirred at 160° C. for 16 h. The mixture was diluted with EtOAc, washed with H2O, brine. The organic fraction was concentrated in vacuo to afford i (1.01 g, 90%). MS: 375.96 [M+H]+.

Workup

washwashed with H2O, brine
concentrationThe organic fraction was concentrated in vacuo
customto afford i (1.01 g, 90%)

Sources & evidence

ORD record: ord-279f9305c2e5458db8c729488d747fca
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906902B2

Reaction notes

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