Hydrochloric Acid → HCID 67980924, compound

HRID 1400042Notes

Reaction equation

HRID 1400042 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]2[C:10]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][C@H:23]([CH2:25][NH:26][C:27]([O:29][CH3:30])=[O:28])[O:22][C:21]4=[O:31])=[CH:16][CH:15]=3)([CH2:11]2)[CH2:9]1)=[O:7])(C)(C)C.Cl>C(OCC)C>[CH3:1][O:5][C:6]([N:8]1[CH2:13][CH:12]2[C:10]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][C@H:23]([CH2:25][NH:26][C:27]([O:29][CH3:30])=[O:28])[O:22][C:21]4=[O:31])=[CH:16][CH:15]=3)([CH2:11]2)[CH2:9]1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67508140HCID 67508140, compound

Product 1

HCID 67980924HCID 67980924, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of compound (310 mg, 0.72 mmol) obtained in Step 2, in diethylether (10 mL) was passed HCl gas for about 30 min. at r.t. The solid precipitates were washed with diethylether (10 mL) and ethyl acetate (10 mL) and dried under reduced pressure to give the title compound.

Workup

  1. customfor about 30 min.
  2. customat r.t
  3. customThe solid precipitates
  4. washwere washed with diethylether (10 mL) and ethyl acetate (10 mL)
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-d508b784162949099383654436e1da1f
Source dataset
uspto-grants-2014_12
Patent number
US08906913B2

Reaction notes

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