Tetrahydrofuran → HCID 67153997, compound

HRID 1400162Notes

Reaction equation

HRID 1400162 reaction equation
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)([CH2:6][CH2:7][CH3:8])[C:3]([OH:5])=[O:4].O1CC[CH2:20][CH2:19]1>[Pd]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([C:2]([CH3:1])([CH2:6][CH2:7][CH3:8])[C:3]([O:5][CH2:19][CH3:20])=[O:4])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 67154002HCID 67154002, compound

Product 1

HCID 67153997HCID 67153997, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
23 °C

Procedure

2.6 g of 2-methyl-2-(4-nitrophenyl)pentanoic acid are dissolved in 30 ml of tetrahydrofuran, 1 g of 5% Pd/C (52.3% of water) is added, and the mixture is stirred at 23° C. under a hydrogen atmosphere for 1 h. After aeration, the solid material is filtered off, and the filtrate is evaporated to dryness in vacuo. Yield: 2.2 g (95%) of ethyl 2-(4-aminophenyl)-2-methylpropanoate; LC-MS retention time: 1.99 min.

Workup

  1. filtrationAfter aeration, the solid material is filtered off
  2. customthe filtrate is evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-3209ae0b067444d8866e4064590f2dd6
Source dataset
uspto-grants-2014_12
Patent number
US08906930B2

Reaction notes

Loading…