Trifluoroacetic acid → HCID 67154034, compound

HRID 1400166Notes

Reaction equation

HRID 1400166 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C:9]1[N:18]=[C:17]([C:19]([N:21]2[CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22]2)=[O:20])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:30]([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:31][C:32](=[CH2:40])[C:33]([O:35]C(C)(C)C)=[O:34])[CH:15]=2)[N:10]=1>ClCCl>[CH2:44]([O:43][C:41](=[O:42])[CH:30]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([NH2:8])[N:18]=[C:17]2[C:19]([N:21]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22]1)=[O:20])[CH2:31][C:32](=[CH2:40])[C:33]([OH:35])=[O:34])[CH3:45]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68227620HCID 68227620, compound

Product 1

HCID 67154034HCID 67154034, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
23 °C

Procedure

200 μl of trifluoroacetic acid are added to 100 mg of O1-tert-butyl O5-ethyl 4-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-2-methylenepentanedioate in 1 ml of dichloromethane, and the mixture is stirred at 23° C. for 3 h. The mixture is subsequently evaporated to dryness in vacuo and reacted further directly.

Workup

  1. customThe mixture is subsequently evaporated to dryness in vacuo
  2. customreacted further directly

Sources & evidence

ORD record
ord-2539bd1014ce4e798f17331c5eb6fb67
Source dataset
uspto-grants-2014_12
Patent number
US08906930B2

Reaction notes

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