反应详情

温度

110 °C

A mixture of ethyl 2-chloronicotinate (100 mg, 0.539 mmol), 2-(tributylstannyl)benzo[d]oxazole (314 mg, 0.539 mmol) and [1,1′-bis(diphenylphosphino) ferrocene]-dichloropalladium (II) (39.4 mg, 0.054 mmol) in DMF (2 mL) was heated to 110° C. for 1 h by applying microwave radiation to the mixture. The reaction was repeated on the same scale and the thus obtained reaction mixtures obtained were combined. Excess water and EtOAc were added. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with water and dried over MgSO4. Purification by flash column chromatography (EtOAc/DCM, gradient: 1-10% DCM) provided the title compound (290 mg, 90%);

1. customthe thus obtained reaction mixtures
2. customobtained
3. customThe organic layer was separated
4. extractionthe aqueous layer was extracted with EtOAc
5. washThe combined organic layers were washed with water
6. dry with materialdried over MgSO4
7. customPurification by flash column chromatography (EtOAc/DCM, gradient: 1-10% DCM)