反应详情

温度

65 °C

DMSO is added to NaH 60% dispersion in oil (1-1.8 equiv.) and heated to 65° C. for 1 h. THF is added to the mixture at the same temperature and heated for another 10 min. After 10 min., the reaction mixture is cooled to 0° C. Trimethylsulfonium iodide (1-1.2 equiv.) is added and the contents are stirred for 10 min. A solution of 6-methylnicotinaldehyde (1 equiv.) in THF is added dropwise. After complete addition, the reaction mixture is stirred at RT for 2 h, and monitored by LCMS. The reaction mixture is poured in ice water, extracted in diethyl ether, dried over sodium sulfate and concentrated at 25° C. to get crude product 2-methyl-5-(oxiran-2-yl)pyridine.

1. temperatureheated for another 10 min
2. temperaturethe reaction mixture is cooled to 0° C
3. additionAfter complete addition
4. stirringthe reaction mixture is stirred at RT for 2 h
5. extractionextracted in diethyl ether
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated at 25° C.