1,2-Dichloroethane → HCID 86710767, compound

HRID 1400713Notes

Reaction equation

HRID 1400713 reaction equation
[CH2:1]([CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]3[N:19]4[N:20]=[C:21](C5C=C(C6C=CC=CC=6CCC=C)C=CC=5)[CH:22]=[C:18]4[N:17]=[C:16]([CH3:39])[C:15]=3[C@H:40]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])[C:41]([O:43][CH3:44])=[O:42])[CH:12]=2)[O:7][CH2:6][CH2:5]1)[CH:2]=[CH2:3].Cl[CH2:51][CH2:52]Cl>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C(OC(C)C)=CC=CC=3)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1>[C:46]([O:45][C@@H:40]([C:15]1[C:16]([CH3:39])=[N:17][C:18]2=[CH:22][C:21]3=[N:20][N:19]2[C:14]=1[C:11]1[CH:12]=[C:13]2[C:8]([O:7][CH2:6][CH2:5][CH:4]2[CH2:1][CH:2]=[CH:3][CH2:15][CH2:14][C:11]2[CH:10]=[CH:9][CH:8]=[CH:13][C:12]=2[C:52]2[CH:51]=[C:3]3[CH:2]=[CH:1][CH:4]=2)=[CH:9][CH:10]=1)[C:41]([O:43][CH3:44])=[O:42])([CH3:49])([CH3:47])[CH3:48]

Participants

4

Reactant 2

HCID 111,2-DichloroethaneHCID 89971438HCID 89971438, compound

Product 1

HCID 86710767HCID 86710767, compound

Reagents, catalysts & solvents 1

HCID 11763533(1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)rutheniumCatalyst

Procedure

A solution of (2S)-methyl 2-(7-(4-allylchroman-6-yl)-2-(2′-(but-3-en-1-yl)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (0.054 g, 0.082 mmol) in DCE (5.0 mL) was heated (70° C.), then treated with Hoveyda-Grubbs Cat. 2nd Gen. (5 mg, 8 μmol). The reaction was stirred for 90 min. The reaction was cooled, then concentrated and the residue was used immediately in the following step. LCMS (M+H)=628.4.

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-fba07feb289d4b968f495bdf3bcbedeb
Source dataset
uspto-grants-2014_12
Patent number
US08906929B2

Reaction notes

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