Hydrochloric Acid → HCID 67443653, compound

HRID 1400839Notes

Reaction equation

HRID 1400839 reaction equation
[F:1][C:2]1[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3[N:15]([CH3:31])[C:16]([CH2:19][NH:20][CH2:21][CH2:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[CH:17][N:18]=3)[S:13][C:6]=12.Cl>C(Cl)Cl>[F:1][C:2]1[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3[N:15]([CH3:31])[C:16]([CH2:19][NH:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:17][N:18]=3)[S:13][C:6]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117653013HCID 117653013, compound

Product 1

HCID 67443653HCID 67443653, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 132 (272 mg, 0.502 mmol) in DCM (10 mL) was added HCl (4 M in Et2O) (0.502 mg, 2.009 mmol) and the reaction mixture was stirred at RT for 4 hours. The reaction mixture was then concentrated to afford title compound 133 as a yellow solid (244 mg, 100% yield, crude) that was used in the next step with no additional purification. MS (m/z)=486.1 (M+H).

Workup

  1. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-fdc83b418e764cb383983eccd7b63a90
Source dataset
uspto-grants-2014_12
Patent number
US08906852B2

Reaction notes

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