1,4-Dioxane → 4-Chloro-6-(3,3-difluoropyrrolidin-1-yl)pyrimidine
Reaction equation
[CH2:25]1[O:26][CH2:27][CH2:28][O:29][CH2:30]1.[CH:16]([N:17]([CH2:18][CH3:19])[CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[Cl:8][c:9]1[n:10][cH:11][n:12][c:13]([Cl:15])[cH:14]1.[F:1][C:2]1([F:7])[CH2:3][NH:4][CH2:5][CH2:6]1>>[F:1][C:2]1([F:7])[CH2:3][N:4]([c:13]2[n:12][cH:11][n:10][c:9]([Cl:8])[cH:14]2)[CH2:5][CH2:6]1Participants
5
Sources & evidence
- ORD record
- ord-48aaa8b636224dd98c6f2e663af5a57a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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