Aluminium lithium hydride → HCID 67323188, compound

HRID 1401786Notes

Reaction equation

HRID 1401786 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C@@H:9]1[C:13]([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[S:22][CH:23]=[C:24]([C:26]3[CH:35]=[CH:34][C:33]4[C:32]([CH3:37])([CH3:36])[CH2:31][CH2:30][C:29]([CH3:39])([CH3:38])[C:28]=4[CH:27]=3)[N:25]=2)[CH2:17][CH2:16]1)=O>C1COCC1>[CH3:36][C:32]1([CH3:37])[CH2:31][CH2:30][C:29]([CH3:38])([CH3:39])[C:28]2[CH:27]=[C:26]([C:24]3[N:25]=[C:21]([CH:18]4[CH2:17][CH2:16][N:15]([CH2:13][C@@H:9]5[C@@H:8]([OH:7])[CH2:12][CH2:11][NH:10]5)[CH2:20][CH2:19]4)[S:22][CH:23]=3)[CH:35]=[CH:34][C:33]1=2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67323751HCID 67323751, compound

Product 1

HCID 67323188HCID 67323188, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation was carried out as already described using a 2N lithium aluminium hydride solution in THF starting from 30 mg (0.06 mmol) of ((2S,3S)-3-hydroxypyrrolidin-2-yl)-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-1-yl}methanone. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-3beb4fc1e3434a808a72517ef4ec76b1
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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