Hydrochloric Acid → HCID 67323363, compound

HRID 1401792Notes

Reaction equation

HRID 1401792 reaction equation
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.C([O:28][C:29](=O)[CH:30]([CH2:36][CH2:37][CH2:38]Cl)[C:31](OCC)=[O:32])C.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:20][CH2:21][N:22]([CH2:38][CH2:37][CH2:36][CH:30]([CH2:31][OH:32])[CH2:29][OH:28])[CH2:23][CH2:24]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 140413Malonic acid, 3-chloropropyl-, diethyl esterHCID 21226445Aluminium lithium hydrideHCID 53312286HCID 53312286, compound

Product 1

HCID 67323363HCID 67323363, compound

Procedure

The preparation was carried out analogously as described above starting from 200 mg (0.53 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine and 234 μl (0.1.06 mmol) of 2-(3-chloropropyl)malonic acid diethyl ester and subsequent reduction using lithium aluminium hydride prepared. The product is in the form of the hydrochloride.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-15672ffc8e704750b03ca3868a781ab6
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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