Hydrochloric Acid → HCID 67322851, compound

HRID 1401804Notes

Reaction equation

HRID 1401804 reaction equation
Cl.[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2.Cl[CH2:28][CH2:29][O:30][CH2:31][CH2:32][OH:33].Cl>>[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([CH:20]4[CH2:25][CH2:24][N:23]([CH2:28][CH2:29][O:30][CH2:31][CH2:32][OH:33])[CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 123612-(Chloroethoxy)ethanolHCID 67166643HCID 67166643, compound

Product 1

HCID 67322851HCID 67322851, compound

Procedure

The preparation was carried out as already described starting from 100 mg (0.26 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine hydrochloride and 34 μl (0.31 mmol) of 2-(2-chloroethoxy)ethanol. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-0c51f7ada4ef41b19a14e7cb95ed4a32
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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