Trifluoroacetic acid → HCID 67325216, compound

HRID 1401809Notes

Reaction equation

HRID 1401809 reaction equation
C(O)(C(F)(F)F)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:35]=[CH:34][C:33]4[C:32]([CH3:37])([CH3:36])[CH2:31][CH2:30][C:29]([CH3:39])([CH3:38])[C:28]=4[CH:27]=3)[CH:22]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[CH3:36][C:32]1([CH3:37])[CH2:31][CH2:30][C:29]([CH3:38])([CH3:39])[C:28]2[CH:27]=[C:26]([C:23]3[CH:22]=[C:21]([N:18]4[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]4)[O:25][N:24]=3)[CH:35]=[CH:34][C:33]1=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 67322507HCID 67322507, compound

Product 1

HCID 67325216HCID 67325216, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The protecting group was cleaved off as already described using TFA in DCM starting from 27 mg (0.06 mmol) of 4-[3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)isoxazol-5-yl]piperazine-1-carboxylic acid tert-butyl ester from step d. The product is in the form of the TFA salt.

Sources & evidence

ORD record
ord-9d75e37e6abc46ffb0e36bbba6ea0ab1
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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