Hydrochloric Acid → HCID 67324404, compound

HRID 1401831Notes

Reaction equation

HRID 1401831 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][CH:12]([N:15]2[CH:19]=[C:18]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:17]=[N:16]2)[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[CH3:30][C:26]1([CH3:31])[CH2:25][CH2:24][C:23]([CH3:32])([CH3:33])[C:22]2[CH:21]=[C:20]([C:18]3[N:17]=[N:16][N:15]([CH:12]4[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]4)[CH:19]=3)[CH:29]=[CH:28][C:27]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67324522HCID 67324522, compound

Product 1

HCID 67324404HCID 67324404, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The protecting group was cleaved off as already described using HCl in dioxane starting from 120 mg (0.27 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,2,3-triazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester from step a. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-1b6fe845b21c4dbfb0f4467a82243a7a
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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