Aluminium lithium hydride → HCID 67324158, compound

HRID 1401834Notes

Reaction equation

HRID 1401834 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH2:13][CH2:12]2)=[N:8][C:7]=1[C:22]1[CH:31]=[CH:30][C:29]2[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]([CH3:35])([CH3:34])[C:24]=2[CH:23]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[OH:3][CH2:4][C:6]1[S:10][C:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH2:15][CH2:16]2)=[N:8][C:7]=1[C:22]1[CH:31]=[CH:30][C:29]2[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]([CH3:35])([CH3:34])[C:24]=2[CH:23]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53311875HCID 53311875, compound

Product 1

HCID 67324158HCID 67324158, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation was carried out as already described starting from 2-[4-(4-hydroxybutyl)piperazin-1-yl]-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-5-carboxylic acid ethyl ester by reduction using a lithium aluminium hydride solution in THF.

Sources & evidence

ORD record
ord-3291e30e70764fd0a47b02d87e07bf86
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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