反应详情

温度

80 °C

1 g (4.12 mmol) of 2,4-dibromothiazole was dissolved in 10 ml of DMF, 1.06 g (7.82 mmol) of piperidin-4-one hydrochloride and 2.3 ml (16.47 mmol) of triethylamine were added, and the mixture was stirred at 80° C. for 3 days. The reaction mixture was stirred into 300 ml of water and extracted by shaking with EA. The organic phase was dried over sodium sulfate, filtered and evaporated. The purification was carried out by means of flash chromatography on silica gel.

1. extractionextracted
2. stirringby shaking with EA
3. dry with materialThe organic phase was dried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe purification